Author

Dove J. Keith

Oregon Health & Science University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

Rosalie C. SearsiD· 4 shared Koei ChiniD· 3 shared Vidhi M. ShahiD· 3 shared Alexander SmithiD· 2 shared Aubry Matter· 2 shared Canping CheniD· 2 shared Charles D. LopeziD· 2 shared Colin J. DanieliD· 2 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

Rosalie C. SearsORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A window trial in metastatic pancreatic ductal adenocarcinoma reveals resistance mechanisms to targeting the KRAS-MEK pathway

Motoyuki Tsuda, Dove J. Keith, Colin J. Daniel, Carl Pelz, Katie E. Blise, Tugba Y. Ozmen, Furkan Ozmen, Kevin Hawthone, Jennifer R. Eng, Xi Li, Xiaoyan Wang, Hayley Zimny, Shamilene Sivagnanam, Konjit Betre, Nell C. Kirchberger, , Rosalie C. Sears

The paper identifies resistance mechanisms to KRAS-MEK pathway targeting in PDAC by analyzing clinical trial data and multi-omics profiles, showing that KRAS/MYC co-gain correlates with resistance and that co-targeting these genes is synergistic.

bioRxiv · Dec 15, 2025 · PreprintCancer Biology

Tumor-intrinsic MHC-II activation in pancreatic ductal adenocarcinoma enhances immune response and treatment efficacy

Canping Chen, Kyle P. Gribbin, Xi Li, Tugba Y. Ozmen, Furkan Ozmen, Shamilene Sivagnanam, James Kim, Katie E. Blise, Xinxing Yang, Yi Zhang, Roselyn S Dai, Dove J. Keith, Mara H. Sherman, Mu‐Shui Dai, Lisa M. Coussens, , Zheng Xia

This study shows that MHC-II expression in pancreatic cancer cells correlates with immune infiltration and improves immunotherapy response in mouse models.

bioRxiv · Oct 21, 2025 · PreprintCancer Biology

PIN1 Drives Cellular Plasticity and Immune Modulation in Chronic Pancreatitis

Vidhi M. Shah, Alexandra Q. Bartlett, Canping Chen, Aubry Matter, Alexander Smith, Hayley Zimny, Xiaoyan Wang, Colin J. Daniel, Jenny Eng, Syber Haverlack, Isaac Youm, Motoyuki Tsuda, Nicholas L. Calistri, Matthew Reyer, Terry K. Morgan, , Rosalie C. Sears

This study shows PIN1 promotes cellular plasticity and immune changes in chronic pancreatitis, with genetic or pharmacological inhibition reducing disease severity.

bioRxiv · May 13, 2025 · PreprintCell Biology

HMG Box-Containing Protein 1 (HBP1) Protects Against Pancreatic Injury in Acute Pancreatitis but Promotes Neoplastic Progression.

Seung-Won Lee, Taelor J. Ekstrom, Elise C. Manalo, Shangyuan Ye, Mark Berry, Dmytro Grygoryev, Malwina Szczepaniak, Jinho Lee, Carlos A. Origel Marmolejo, Syber Haverlack, Ju Young Lee, Vidhi M. Shah, Dove J. Keith, John L. Muschler, Koei Chin, , Jungsun Kim

This study shows HBP1 protects against acute pancreatitis but promotes pancreatic cancer progression in the presence of KRAS mutations.

Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2025Peer-reviewedCell Biology