Author

Francesco Puzzo

Stanford MedicineORCID 0000-0001-9936-8873Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Organism:mouse· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Magdalena P. CrossleyiD· 2 shared Aranyak GoswamiiD· 1 shared Cameron J. CheeiD· 1 shared Feijie Zhang· 1 shared Hassan MassalhaiD· 1 shared Jada L. GarzoniD· 1 shared Julia S. P. MaweriD· 1 shared Karlene A. CimprichiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

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10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

Magdalena P. CrossleyORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintApr 8, 2026

Protocol for in vivo DNA-RNA hybrid immunoprecipitation sequencing and analysis from frozen mammalian tissues

Hassan Massalha, Cameron J. Chee, Julia S. P. Mawer…·Magdalena P. Crossley

This paper describes a protocol for isolating and sequencing DNA-RNA hybrids from frozen mouse tissues to map R-loop profiles.

DOI 10.64898/2026.04.06.716701

mouseDNA methylation

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Molecular BiologyMolecular TherapyPeer-reviewedOct 4, 2024

AAV-mediated genome editing is influenced by the formation of R-loops

Francesco Puzzo, Magdalena P. Crossley, Aranyak Goswami…·Mark A. Kay

This study shows that R-loop formation enhances AAV-mediated genome integration, particularly in highly transcribed genes, and correlates with off-target integration sites.

4 citations

mouseDNA methylation

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