Magdalena P. Crossley

This paper describes a protocol for isolating and sequencing DNA-RNA hybrids from frozen mouse tissues to map R-loop profiles.

This study shows that R-loop formation enhances AAV-mediated genome integration, particularly in highly transcribed genes, and correlates with off-target integration sites.

This paper shows that HLTF has two roles in managing G4s: preventing their accumulation and slowing replication forks to maintain genome stability.

The paper maps R-loops in neural stem/progenitor cells and finds they are associated with early replicating, transcribed regions but not with recurrent DSB clusters in long genes.

qDRIP quantitatively compares RNA:DNA hybrids in different conditions to estimate their absolute counts and half-lives.