Jason J. Early

This study identifies FBXW7 as a regulator of myelin capacity and homeostasis in the adult CNS by controlling MYRF levels through ubiquitination.

The paper identifies importin 13b's role in axon diameter growth and shows its impact on conduction velocity in myelinated axons in zebrafish.

The paper identifies a conserved myelination mechanism in oligodendrocytes that forms paranodal bridges, enabling extended myelin sheaths along axons, which degenerate more frequently with age.

The paper compares remyelination by surviving and newly generated oligodendrocytes in MS, finding that newly generated cells produce more accurate and abundant myelin sheaths.

This study shows that hypomyelination in zebrafish larvae disrupts axonal conduction and behavior, linking myelination to neural circuit function.

This study shows that disrupting NKCC1 in Schwann cells impairs their response to neuronal activity, leading to myelin defects and nerve pathology, which can be reversed by TTX treatment.