Anna Williams

This study shows FGF signaling induces disease-associated oligodendrocyte states and causes myelin pathology in both in vitro and in vivo models.

This study shows microglia drive myelin loss in MS through autoantibodies and BTK signaling, with implications for therapeutic targeting.

This study identifies cognitive impairment and white matter defects in a mouse model of cerebral small vessel disease caused by Col4a1 mutations and shows that targeting protein folding can alleviate these issues.

The paper identifies the prefrontal cortex as the most vulnerable BBB region to ageing in mice by analyzing molecular, structural, and functional changes across three brain regions.

The paper uses single nuclei RNAseq to identify distinct glial gene expression patterns in MS patients, revealing subgroup-specific pathological processes and suggesting precision medicine approaches.

This study identifies proteomic differences in neutrophils from MS patients compared to healthy donors, highlighting dysregulated granule proteins and MAVS signaling, and impaired T cell suppression.

This study uses snRNAseq to analyze glial cell heterogeneity in Huntington's disease across brain regions, identifying subtype-specific changes and potential mechanisms of glial dysfunction.

The paper profiles histone modifications in adult human CNS cells, revealing epigenetic memory of developmental programs in oligodendroglia.

The paper shows that astrocyte-oligodendrocyte interaction is critical for remyelination and identifies a drug strategy targeting this interaction to promote central nervous system regeneration.

The paper identifies regional glial heterogeneity in human white matter using single nucleus RNA sequencing, revealing tissue-specific glial populations and age/sex-related gene expression differences.

AimSeg is a machine learning tool for segmenting axons, inner tongue, and myelin in EM images, improving efficiency and accuracy over manual methods.

The paper identifies a conserved myelination mechanism in oligodendrocytes that forms paranodal bridges, enabling extended myelin sheaths along axons, which degenerate more frequently with age.

The paper compares remyelination by surviving and newly generated oligodendrocytes in MS, finding that newly generated cells produce more accurate and abundant myelin sheaths.

This study identifies intrinsic endothelial dysfunction as a cause of cerebral small vessel disease in a normotensive rat model, independent of hypertension.

This paper investigates whether demyelination in multiple sclerosis leads to selective neurodegeneration of inhibitory interneurons and presents a rodent model to study this phenomenon.