Tina Notter

This study shows that abnormal astrocyte activity during adolescent prefrontal cortex development leads to synaptic loss, interneuron dysfunction, and cognitive deficits.

The paper characterizes synaptic dynamics during normal mouse prefrontal cortex maturation using combined imaging and quantification methods.

This study shows that overactivation of prefrontal astrocytes in mice impairs cognition and PV interneuron function through increased kynurenine pathway metabolite KYNA.