Matthias Tasso Wyss

This paper introduces an in vivo model for focal astrocyte ablation combined with longitudinal two-photon imaging to study CNS responses to astrocyte loss.

The paper introduces ECgo, an optical method to induce single endothelial cell injury and capillary occlusion in the mouse brain with high spatial precision, enabling studies of capillary repair and dysfunction.

The paper characterizes synaptic dynamics during normal mouse prefrontal cortex maturation using combined imaging and quantification methods.

The paper shows pial collaterals propagate neurovascular signals between cortical territories, synchronizing blood flow responses beyond activated areas.

This paper introduces a low-cost FPGA-based method to correct pile-up distortions in TCSPC-FLIM, enabling high-speed, accurate in vivo imaging with subcellular resolution.

This paper develops a new imaging technique to study brain perfusion in mice during ischemic stroke, showing its ability to map vascular changes and assess therapeutic effects.

This study shows that overactivation of prefrontal astrocytes in mice impairs cognition and PV interneuron function through increased kynurenine pathway metabolite KYNA.

The paper investigates mitochondrial lactate metabolism, finding that mitochondria produce lactate as an overflow mechanism to regulate redox levels and conserve energy.

The paper shows that mature astrocytes can transform into progenitor-like cells to regenerate astrocytic networks after injury in mice.

This study shows that leptomeningeal collaterals regulate reperfusion in ischemic stroke, with poor collaterals leading to hemorrhage and poor outcomes.