High throughput identification of genetic regulators of microglial inflammatory processes in Alzheimer's disease
Christopher L. Cardona, Lai Wei, Joonwon Kim, Ellen Angeles, Gunjandeep Singh, Shiye Chen, Ronak Patel, Nkechime Ifediora, Peter Canoll, Andrew F. Teich, Gunnar Hargus, Alejandro Chavez, Andrew A. Sproul
This study identifies genetic regulators of microglial inflammation in Alzheimer's disease using CRISPRi screens and scRNA-seq, revealing key genes that modulate inflammatory states and disease-relevant clusters.
Journal of Neuroinflammation · Dec 3, 2025Peer-reviewedNeuroscience