Ellen Angeles

This study identifies a resistance mechanism in AML leukemic stem cells to PI3K inhibition and shows that combining PI3K and EZH1/2 inhibitors overcomes resistance.

The paper identifies protective SH3RF3 variants that delay Alzheimer's onset by reducing microglial inflammation through JNK and NFkB pathway modulation in PSEN1G206A carriers.

This study identifies genetic regulators of microglial inflammation in Alzheimer's disease using CRISPRi screens and scRNA-seq, revealing key genes that modulate inflammatory states and disease-relevant clusters.

This study identifies TTLL4 as a therapeutic target in NPM1-mutated AML by showing its role in stabilizing NPM1c and promoting differentiation block, with a small molecule inhibitor demonstrating efficacy.

This study shows NSun2 deficiency in AD leads to miR-125b dysregulation and tau hyperphosphorylation, promoting neurodegeneration through epitranscriptomic mechanisms.