Cancer BiologybioRxivPreprint
EcDNA-borne PVT1 fusion stabilizes oncogenic mRNAs
Hyerim Yi, Shu Zhang, Jason T. Swinderman…·Howard Y. Chang
The paper shows that ecDNA-borne PVT1 fusions stabilize oncogenic mRNAs by interacting with SRSF1, enhancing RNA stability and supporting MYC dependency in cancer.
4 citations