EcDNA-borne PVT1 fusion stabilizes oncogenic mRNAs
Hyerim Yi, Shu Zhang, Jason T. Swinderman, Yanbo Wang, Vishnupriya Kanakaveti, King L. Hung, Ivy Tsz-Lo Wong, Suhas Srinivasan, Ellis J. Curtis, Aarohi Bhargava-Shah, Rui Li, Matthew G. Jones, Jens Luebeck, Yanding Zhao, Julia A. Belk, , Howard Y. Chang
The paper shows that ecDNA-borne PVT1 fusions stabilize oncogenic mRNAs by interacting with SRSF1, enhancing RNA stability and supporting MYC dependency in cancer.
bioRxiv · Apr 1, 2025 · PreprintCancer Biology