Author

Patrick Trojer

Constellation Pharmaceuticals (United States)ORCID 0000-0001-9969-9154Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Ah‐Jung JeoniD· 1 shared Anisha B. Tehim· 1 shared Anuradha GopalaniD· 1 shared Barbara M. BryantiD· 1 shared Chih-Chi Yuan· 1 shared Dan LiiD· 1 shared Dana M. Schoeps· 1 shared Ekta KhuranaiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenomics

Ah‐Jung JeonORCID

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2 papers

Recent·Most cited

BET inhibitors as a therapeutic intervention in gastrointestinal gene signature-positive castration-resistant prostate cancer.

Shipra Shukla, Dan Li, Woo Hyun Cho, Dana M. Schoeps, Holly M. Nguyen, Jennifer L. Conner, Marjorie L. Roskes, Anisha B. Tehim, Gabriella Bayshtok, Mohini R. Pachai, Juan Yan, Nicholas A. Teri, Eric Campeau, Sarah Attwell, Patrick Trojer, , Yu Chen

This study identifies BET inhibitors as effective against GI transcriptome-positive CRPC by targeting HNF1A and HNF4G, improving outcomes in preclinical models.

Journal of Clinical Investigation · Jun 24, 2025Peer-reviewedCancer Biology

EZH2 inhibition results in genome-wide PRC2 redistribution

Chih-Chi Yuan, Ah‐Jung Jeon, Greg Tucker‐Kellogg, Barbara M. Bryant, Patrick Trojer

This study shows that EZH2 inhibition causes PRC2 redistribution and H3K27me3 retention at differentiation-related genes, but not all cell lines respond to this treatment.

bioRxiv · Dec 29, 2019 · PreprintGenomics