Author

Tom Bonnifet

Centre National de la Recherche ScientifiqueORCID 0000-0001-9972-0136Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:deep learning· 1 Approach:statistical model· 1

Frequent Co-Authors

Bérangère LombardiD· 2 shared Damarys LoewiD· 2 shared Héloïse MonnetiD· 2 shared Julia FuchsiD· 2 shared Nicolas ServantiD· 2 shared Olivia Massiani-BeaudoiniD· 2 shared Rajiv L. JoshiiD· 2 shared Sandra Sinnassamy· 2 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersNeuroscience

Bérangère LombardORCID

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2 papers

Recent·Most cited

Interactions of the LINE-1 encoded ORF1p with proteins and chromatin converge on a role in neuronal physiology

Sandra Sinnassamy, Olivia Massiani-Beaudoin, Bérangère Lombard, Damarys Loew, Tom Bonnifet, Magali Fradet, Héloïse Monnet, Thomas Caille, Nicolas Servant, Rajiv L. Joshi, Julia Fuchs

This study identifies ORF1p interactions with proteins and chromatin in neurons, showing its role in gene regulation and neurite morphology.

bioRxiv · Sep 5, 2025 · PreprintNeuroscience

Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brain

Tom Bonnifet, Sandra Sinnassamy, Olivia Massiani-Beaudoin, Philippe Mailly, Héloïse Monnet, Damarys Loew, Bérangère Lombard, Nicolas Servant, Rajiv L. Joshi, Julia Fuchs

The paper investigates LINE-1 ORF1p protein and RNA expression in mouse and human brains, finding increased levels with aging and neuron-specific expression patterns.

bioRxiv · Dec 12, 2023Neuroscience