Philippe Mailly

The paper identifies astrocyte perisynaptic processes as sites of early translational dysregulation in Alzheimer's disease, linking it to synaptic dysfunction and disease initiation.

This study shows LOXL2 mediates BM assembly in response to microenvironment topography, affecting endothelial cell behavior and barrier properties.

This study uses 3D vascularized microtumors to reveal distinct vascular structures in ccRCC and their differential response to sunitinib.

This study examines the spatial organization and proximity of macroglial cells to blood vessels during postnatal brain development, revealing distinct developmental patterns for astrocytes and oligodendrocytes.

This study shows that astroglial Ophn1 deficiency impairs synaptic transmission and behavior, with potential therapeutic targeting of the RhoA/ROCK pathway.

The paper shows that excitatory synapses on Purkinje cells develop through a stepwise molecular process involving initial common proteins and later input-specific proteins.

The paper investigates LINE-1 ORF1p protein and RNA expression in mouse and human brains, finding increased levels with aging and neuron-specific expression patterns.

This study shows that ORF1p from LINE-1 retrotransposons translocates to the nucleus under stress, disrupts nuclear envelope integrity, and contributes to neurodegenerative features in neurons.

The paper examines ferritin mRNA density and distribution in hippocampal astrocytes under different iron overload conditions and finds changes in mRNA ratios and localization.

This study shows that sustained Gadd45b overexpression in mice causes DNA methylation changes, heterochromatin disorganization, DNA damage, and dopaminergic neuron death, linking chromatin alterations to neurodegeneration.

The paper compares molecular and functional maturation of brain vascular cells in mice and humans during postnatal development, identifying key markers and processes in endothelial and vascular smooth muscle cells.

The paper identifies a unique molecular repertoire in hippocampal perisynaptic astrocytic processes, regulated by local translation during fear conditioning.

The paper introduces AstroDot, a method to study mRNA distribution in astrocytes, showing Gfap and Gfap delta mRNAs localize with GFAP in processes and show changes in Alzheimer's disease.

This study shows that extracellular Pax6 non-cell autonomously regulates Cajal-Retzius cell migration in the developing mouse neocortex by affecting directionality, distance, and depth of migration.