Engineering immunotoxin-equipped effector cells and evaluation in primary human immune cells
Alexander H. Pearlman, Brian J. Mog, Michael S. Hwang, Jordina Rincón-Torroella, Sarah R. DiNapoli, Suman Paul, Jacqueline Douglass, Emily Han-Chung Hsiue, Stephanie A. Glavaris, Drew M. Pardoll, Nickolas Papadopoulos, Kenneth W. Kinzler, Chetan Bettegowda, Shibin Zhou, Bert Vogelstein, Maximilian F. Konig
This paper engineers effector cells resistant to bacterial toxins to deliver immunotoxins specifically to cancer cells and introduces a platform for therapeutic cell type development.
bioRxiv · Dec 11, 2025 · PreprintMolecular Biology