Suman Paul

Understanding the physiological alterations of Vibrio cholerae upon exposure to L-ascorbic acid

This study investigates how L-ascorbic acid affects the physiology of Vibrio cholerae and supports its use as a non-antibiotic approach to control cholera.

Spatial Regulation of CAR Signaling Enables Logic-Gated Activity

The paper designs an AND-gated CAR T cell receptor called MANTIS that uses extracellular size differences to spatially regulate signaling for precise antigen recognition.

Engineering immunotoxin-equipped effector cells and evaluation in primary human immune cells

This paper engineers effector cells resistant to bacterial toxins to deliver immunotoxins specifically to cancer cells and introduces a platform for therapeutic cell type development.

Precision targeting of autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells

This study develops anti-9G4 CAR-T and TCR-T cells to selectively target autoreactive B cells in SLE, reducing immunosuppression and cytokine toxicity.

A PBD-dimer containing antibody drug conjugate targeting CCRL2 for high-risk MDS/AML

This paper develops an anti-CCRL2 antibody-drug conjugate (ADC) that shows potent cytotoxicity against high-risk MDS/AML cells without harming healthy hematopoietic cells.

Targeting CCRL2 enhances therapeutic outcomes in a tuberculosis mouse model

This study shows that targeting CCRL2 with an antibody-drug conjugate improves TB treatment in mice by reducing inflammation and enhancing immune responses.

CCRL2 promotes the interferon-γ signaling response in myeloid neoplasms with erythroid differentiation and mutated TP53

This study identifies CCRL2 as a driver of IFN-γ signaling in TP53-mutated AML with erythroid differentiation, linking it to disease progression and poor outcomes.