SG33, a vaccine strain of myxoma virus with oncolytic potential, exploits macropinocytosis and clathrin-mediated endocytosis for entry into pancreatic cancer cells.
Nikolaos Kontopoulos, Noémie Delenclos, Lætitia Ligat…·Pierre Cordelier
This study identifies the entry mechanisms of SG33, an oncolytic myxoma virus, into pancreatic cancer cells, showing it uses macropinocytosis and clathrin-mediated endocytosis.