Author

Alexander Patapoff

GenentechORCID 0000-0002-0012-1668Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:metabolomics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Benjamin T. WaltersiD· 2 shared James R. KieferiD· 1 shared Nicholas PatapoffiD· 1 shared Ping WuiD· 1 shared Weiru WangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 7 mutual co-author links

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2 shared papersBioinformatics

Benjamin T. WaltersORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintOct 8, 2026

msengine: Adaptive Open-Source Signal Extraction for HDX MS

Alexander Patapoff, Nicholas Patapoff, Benjamin T. Walters

msengine improves HDX-MS signal extraction by adaptively adjusting mass and retention-time boundaries, increasing accepted targets and reducing processing time.

DOI 10.64898/2026.09.30.755802

metabolomicsstatistical model

𝕏 PostBluesky

BiophysicsJournal of Chemical Information and ModelingPeer-reviewedJun 11, 2025

Integrating Hydrogen Exchange with Molecular Dynamics for Improved Ligand Binding Predictions

Benjamin T. Walters, Alexander W. Patapoff, James R. Kiefer…·Weiru Wang

This paper introduces HX-ESP, a method combining hydrogen exchange data with molecular dynamics to predict ligand binding modes, outperforming flexible docking for conformationally flexible targets.

4 citations

protein structuredeep learning

𝕏 PostBluesky