Benjamin T. Walters

msengine improves HDX-MS signal extraction by adaptively adjusting mass and retention-time boundaries, increasing accepted targets and reducing processing time.

This paper identifies ATF6α as a non-transcriptional regulator of peroxisome quality control through its interaction with ABCD3, and shows how this interaction can be modulated by Ceapin to influence cancer-related processes.

This paper introduces HX-ESP, a method combining hydrogen exchange data with molecular dynamics to predict ligand binding modes, outperforming flexible docking for conformationally flexible targets.

This paper identifies a potent and specific SMARCA2/A4 degrader, G-6599, which works via FBXO22 recruitment and covalent conjugation, offering therapeutic potential.