Ultra-sensitivity metaproteomics redefines the gut dark metaproteome, uncovering host-microbiome interactions and drug targets in intestinal inflammatory diseases.
Feng Xian, Malena Brenek, Christoph Krisp, Elisabeth Urbauer, R. Ranjith Kumar, Doriane Aguanno, Tharan Srikumar, Qixin Liu, Allison M Barry, Bin Ma, Jonathan R. Krieger, Dirk Haller, Manuela Schmidt, David Gómez‐Varela
The paper introduces uMetaP, an ultra-sensitive metaproteomic method that enhances detection of the gut dark metaproteome and identifies drug targets in intestinal inflammatory diseases.
Nature Communications · Jul 18, 2025Peer-reviewedMicrobiology