Allison M Barry

History of opioid use disorder correlates with altered neuroimmune signatures in the human dorsal root ganglia

The paper examines molecular and physiological changes in dorsal root ganglia from individuals with and without opioid use disorder, identifying altered neuroimmune signatures and sensitized sensory neurons.

Precision cell-state silencing of injured afferents alleviates spontaneous neuropathic pain

The paper demonstrates that precision targeting of injured sensory neurons using gene therapy alleviates neuropathic pain in mice.

Proximity labelling reveals the compartmental proteome of murine sensory neurons

This study uses proximity labelling to map the proteome of different compartments in murine sensory neurons, revealing compartment-specific proteomic changes in a neuropathy model.

Progressive neurodegeneration in human dorsal root ganglion from diabetes to painful neuropathy

The paper investigates neurodegeneration in dorsal root ganglia across diabetes and diabetic painful neuropathy stages, identifying early molecular changes and highlighting the need for early intervention.

NKG2D receptor ligands are cell surface biomarkers for injured murine and human nociceptive sensory neurons

Ultra-sensitivity metaproteomics redefines the gut dark metaproteome, uncovering host-microbiome interactions and drug targets in intestinal inflammatory diseases.

The paper introduces uMetaP, an ultra-sensitive metaproteomic method that enhances detection of the gut dark metaproteome and identifies drug targets in intestinal inflammatory diseases.

Single-cell characterization of the human C2 dorsal root ganglion recovered from C1-2 arthrodesis surgery: implications for neck pain

The paper characterizes human C2 dorsal root ganglion (DRG) using single-nucleus and spatial transcriptomics, identifying gene expression patterns linked to chronic neck pain.

Multi-omic integration with human DRG proteomics highlights TNFα signalling as a relevant sexually dimorphic pathway

The paper integrates human DRG proteomics with multi-omic data to identify TNFα signalling as a sexually dimorphic pathway in the PNS.

Peripheral nerve injury results in a biased loss of sensory neuron sub-populations

This study shows that peripheral nerve injury preferentially eliminates specific DRG neuron subpopulations, particularly non-peptidergic nociceptors, and links this loss to neurotrophic support.

Predicting pain genes: multi-modal data integration using probabilistic classifiers and interaction networks

This paper identifies potential pain-related genes using machine learning and interaction networks, finding JAK2/STAT3, ErbB, and Rap1 pathways as promising targets.

A role for LGI1 in regulating pain sensitivity.

This study investigates the role of LGI1 in pain regulation using mouse models, finding that LGI1 ablation in spinal neurons exacerbates neuropathic pain behaviors, suggesting a spinal mechanism for its role in pain sensitivity.

Deep RNA-seq of male and female murine sensory neuron subtypes after nerve injury

The paper analyzes bulk RNA-seq data from murine dorsal root ganglia neurons after nerve injury to identify sex-specific transcriptional changes across neuronal subtypes.