Feng Xian

History of opioid use disorder correlates with altered neuroimmune signatures in the human dorsal root ganglia

The paper examines molecular and physiological changes in dorsal root ganglia from individuals with and without opioid use disorder, identifying altered neuroimmune signatures and sensitized sensory neurons.

Proximity labelling reveals the compartmental proteome of murine sensory neurons

This study uses proximity labelling to map the proteome of different compartments in murine sensory neurons, revealing compartment-specific proteomic changes in a neuropathy model.

Progressive neurodegeneration in human dorsal root ganglion from diabetes to painful neuropathy

The paper investigates neurodegeneration in dorsal root ganglia across diabetes and diabetic painful neuropathy stages, identifying early molecular changes and highlighting the need for early intervention.

Ultra-sensitivity metaproteomics redefines the gut dark metaproteome, uncovering host-microbiome interactions and drug targets in intestinal inflammatory diseases.

The paper introduces uMetaP, an ultra-sensitive metaproteomic method that enhances detection of the gut dark metaproteome and identifies drug targets in intestinal inflammatory diseases.

Multi-omic integration with human DRG proteomics highlights TNFα signalling as a relevant sexually dimorphic pathway

The paper integrates human DRG proteomics with multi-omic data to identify TNFα signalling as a sexually dimorphic pathway in the PNS.

Deep Proteome Profiling Reveals Signatures of Age and Sex Differences in Paw Skin and Sciatic Nerve of Naïve Mice

This study uses deep proteome profiling to identify age and sex differences in mouse paw skin and sciatic nerve, revealing significant protein and network variations with implications for disease models.