A versatile, chemically-controlled DNA binding switch enables temporal modulation of Cas9-based effectors
Cindy T. Wei, Omri Peleg, Elhanan Borenstein, Dustin J. Maly, Douglas M. Fowler
This paper introduces a chemically-controlled DNA binding switch (ciCas9) to enable temporal modulation of Cas9-based effectors, demonstrating its application in base editors and transcriptional activators.
bioRxiv · May 10, 2022 · PreprintMolecular Biology