Liquid-liquid phase separation and liquid-to-solid transition mediate α-synuclein amyloid fibril containing hydrogel formation
Soumik Ray, Nitu Singh, Rakesh Kumar, Komal Patel, Satyaprakash Pandey, Debalina Datta, Jaladhar Mahato, Rajlaxmi Panigrahi, Ambuja Navalkar, Surabhi Mehra, Laxmikant G. Gadhe, Debdeep Chatterjee, Ajay Singh Sawner, S.K. Maiti, Sandhya Bhatia, , Samir Kumar Maji
This study shows that α-synuclein undergoes liquid-liquid phase separation, which transitions to solid amyloid fibrils, contributing to Parkinson's disease pathogenesis.
Nature Chemistry · Jun 8, 2020Peer-reviewedNeuroscience