Author

G. Krishnamoorthy

Anna University, Chennai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cancer Biology· 1 Microbiology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

S. Ray· 2 shared A. Chowdhury· 1 shared A. S. Sawner· 1 shared Ajay Singh SawneriD· 1 shared Ambuja NavalkariD· 1 shared Arindam ChowdhuryiD· 1 shared Ashutosh KumariD· 1 shared B. Xu· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiochemistry

S. Ray

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Telomerase reactivation induces progression of mouse BrafV600E-driven thyroid cancers without telomere lengthening

I. Landa, C. E. Thornton, B. Xu, J. Haase, G. Krishnamoorthy, J. Hao, J. A. Knauf, Z. T. Herbert, M. A. Blasco, R. Ghossein, J. A. Fagin

This study shows that reactivating telomerase in mouse thyroid cancers driven by BrafV600E leads to progression to poorly differentiated tumors without telomere lengthening.

bioRxiv · Jan 24, 2023 · PreprintCancer Biology

Phenol Sensing in Nature Modulated via a Conformational Switch Governed by Dynamic Allostery

J. Singh, M. Sahil, S. Ray, C. Dcosta, S. Panjikar, G. Krishnamoorthy, J. Mondal, R. Anand

The paper shows that MopR, an NtrC protein, uses dynamic allostery to sense phenol, altering its conformation and ATPase activity, with implications for evolutionary conservation.

bioRxiv · May 18, 2022Biochemistry

Spatiotemporal solidification of α-synuclein inside the liquid droplets

S. Ray, D. Chatterjee, S. Mukherjee, K. Patel, J. K. Mahato, S. Kadam, R. Krishnan, A. S. Sawner, M. Poudyal, G. Krishnamoorthy, A. Chowdhury, R. Padinhateeri, S. K. Maji

This study investigates the spatiotemporal solidification of α-synuclein within liquid droplets, showing how solid-like cores form and propagate during droplet aging and fusion.

bioRxiv · Oct 20, 2021 · PreprintBiophysics

Liquid-liquid phase separation and liquid-to-solid transition mediate α-synuclein amyloid fibril containing hydrogel formation

Soumik Ray, Nitu Singh, Rakesh Kumar, Komal Patel, Satyaprakash Pandey, Debalina Datta, Jaladhar Mahato, Rajlaxmi Panigrahi, Ambuja Navalkar, Surabhi Mehra, Laxmikant G. Gadhe, Debdeep Chatterjee, Ajay Singh Sawner, S.K. Maiti, Sandhya Bhatia, , Samir Kumar Maji

This study shows that α-synuclein undergoes liquid-liquid phase separation, which transitions to solid amyloid fibrils, contributing to Parkinson's disease pathogenesis.

Nature Chemistry · Jun 8, 2020Peer-reviewedNeuroscience

Inhibition of host Lactate dehydrogenase A by a small-molecule limits Mycobacterium tuberculosis growth and potentiates bactericidal activity of isoniazid

G. Krishnamoorthy, P. Kaiser, U. Abu Abed, J. Weiner, P. Moura-Alves, V. Brinkmann, S. H. E. Kaufmann

This paper shows that inhibiting host LDHA with FX11 limits M. tuberculosis growth and enhances the effectiveness of isoniazid in a mouse model of TB.

bioRxiv · May 7, 2019 · PreprintMicrobiology