Daniel Andrew Beard

This paper analyzes coronary flow waveforms using SVD to identify temporal patterns correlated with physiological metrics in pigs.

This paper develops a microstructurally-motivated model of coronary autoregulation that accurately reproduces hemodynamics and autoregulatory responses across myocardial depths.

This paper develops a multiscale computational model to simulate cardiopulmonary effects of postnatal hyperoxia in rats, showing agreement with experimental data and capturing abnormalities seen in preterm humans.

The paper uses experimental and computational methods to analyze mitochondrial energy metabolism in cardiac mitochondria, revealing new insights into substrate transport, TCA cycle kinetics, and oxidative phosphorylation.

This paper develops a kinetic model to interpret mant-ATP fluorescence decay in myosin SRX state measurements, showing that decay phases result from label redistribution, not equilibrium states.

This paper develops a theoretical model to explain power-law stress relaxation and calcium-dependent passive mechanics in cardiac muscle by simulating domain unfolding in titin.

This study shows that Ca2+ increases cardiac muscle viscoelasticity independently of active force development, with a >6-fold increase in apparent viscoelasticity at higher Ca2+ levels.

This paper develops a quantitative systems pharmacology model to study mitochondrial metabolism in heart failure and predicts how changes in metabolic pathways affect exercise capacity.

The paper develops a computational model of glycolysis and oxidative phosphorylation in FOG muscle fibers, revealing how metabolic flexibility and LDH contribute to redox balance and ATP homeostasis.

This study shows that reduced mitophagy in aortic smooth muscle cells due to Parkin deficiency worsens abdominal aortic aneurysm progression.

This study identifies unique metabolic adaptations in Acomys cardiomyocytes that enhance cardiac recovery after myocardial infarction compared to Mus musculus.

This study identifies FMO-2's role in promoting longevity in C. elegans by rewiring one carbon metabolism and tryptophan metabolism, linking a single enzyme to metabolic pathways involved in lifespan extension.

The paper uses dynamic network analysis to study how human fibroblasts respond to physical and biochemical cues, identifying key transcription factors involved in mechanotransduction pathways.