Amanda M. Brandow

This study shows that lifelong hydroxyurea treatment reduces chronic pain in sickle cell disease mice by decreasing immune activity and reversing TRPA1 sensitization.

The paper identifies gut microbiota and metabolites as drivers of chronic sickle cell disease pain by altering vagus nerve activity.

The paper uses SCD patient-derived iPSCs to study sensory neuron function and identifies plasma factors that sensitize neurons to pain stimuli.