Author

Charlotte Franck

The University of SydneyORCID 0000-0002-0078-7953Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Joel P. MackayiD· 2 shared Karishma PateliD· 2 shared Richard J. PayneiD· 2 shared Xavier J. Reid· 2 shared Alexander R. NormaniD· 1 shared Andrea DanersiD· 1 shared Biswaranjan MohantyiD· 1 shared Cameron Taylor· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiochemistry

Joel P. MackayORCID

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2 papers

Recent·Most cited

BiochemistryNucleic Acids ResearchPeer-reviewedNov 26, 2025

The BRD4-nucleosome interaction is enhanced modestly and non-selectively by histone acetylation

L. Lambrechts, Xavier J. Reid, Lucas Kambanis…·Joel P. Mackay

This study investigates BRD4's nucleosomal binding affinity and shows that histone acetylation modestly enhances this interaction, with little dependence on acetylation pattern.

8 citations

ChIP-seqproteomics

𝕏 PostBluesky

BiochemistrybioRxivPreprintSep 24, 2025

Peptide molecular glues select between BET paralogues by exploiting allosteric sites and conformational dynamics

Karishma Patel, Biswaranjan Mohanty, Alexander R. Norman…·Joel P. Mackay

The paper identifies cyclic peptides that selectively inhibit BET BD paralogues by exploiting sequence differences and conformational dynamics, achieving high selectivity over existing inhibitors.

DOI 10.1101/2025.09.24.678353

protein structureexperimental assay

𝕏 PostBluesky