BiochemistrybioRxivPreprint
Peptide molecular glues select between BET paralogues by exploiting allosteric sites and conformational dynamics
Karishma Patel, Biswaranjan Mohanty, Alexander R. Norman…·Joel P. Mackay
The paper identifies cyclic peptides that selectively inhibit BET BD paralogues by exploiting sequence differences and conformational dynamics, achieving high selectivity over existing inhibitors.
DOI 10.1101/2025.09.24.678353