Author

Xavier J. Reid

The University of Sydney

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:ChIP-seq· 1 Assay:cryo-EM· 1

Frequent Co-Authors

Joel P. MackayiD· 3 shared Charlotte FranckiD· 2 shared Jason K. K. LowiD· 2 shared Karishma PateliD· 2 shared Richard J. PayneiD· 2 shared Yichen ZhongiD· 2 shared Alastair G. StewartiD· 1 shared Alexander R. NormaniD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersBiochemistry

Joel P. MackayORCID

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Author profile →

3 papers

Recent·Most cited

The BRD4-nucleosome interaction is enhanced modestly and non-selectively by histone acetylation

L. Lambrechts, Xavier J. Reid, Lucas Kambanis, Clement Luong, Erekle Kobakhidze, Andrea Daners, Yichen Zhong, Karishma Patel, Charlotte Franck, Hakimeh Moghaddas Sani, Cameron Taylor, J. Low, Richard J. Payne, Joel P. Mackay

This study investigates BRD4's nucleosomal binding affinity and shows that histone acetylation modestly enhances this interaction, with little dependence on acetylation pattern.

Nucleic Acids Research · Nov 26, 2025Peer-reviewedBiochemistry

The structure and composition of native human nucleosomes

Xavier J. Reid, Meghna Sobti, Yi C. Zeng, Yichen Zhong, Chandrika N. Deshpande, Paul Young, Simon H. J. Brown, Jason K. K. Low, Alastair G. Stewart, Joel P. Mackay

This study reports the high-resolution cryo-EM structure of native human nucleosomes from HEK293 cells and provides mass spectrometry analysis of histone modifications.

bioRxiv · Oct 10, 2025 · PreprintBiochemistry

Peptide molecular glues select between BET paralogues by exploiting allosteric sites and conformational dynamics

Karishma Patel, Biswaranjan Mohanty, Alexander R. Norman, Charlotte Franck, Petr Pachl, Lihua Yang, Xuefei Jing, Xavier J. Reid, James L. Walshe, Paul D. Solomon, Daniel H. Tran, Daniel Ford, Jason K. K. Low, Lorna E. Wilkinson‐White, Toby Passioura, , Joel P. Mackay

The paper identifies cyclic peptides that selectively inhibit BET BD paralogues by exploiting sequence differences and conformational dynamics, achieving high selectivity over existing inhibitors.

bioRxiv · Sep 24, 2025 · PreprintBiochemistry