Author

Bo Chen

Yunnan UniversityORCID 0000-0002-0079-4686Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Bo Chen2 papers · Polar Research Institute of China

Biology Disciplines

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Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Cheng PengiD· 2 shared Chengxiang Deng· 2 shared Jia HeiD· 2 shared Weiju Lu· 2 shared Zhao ShaniD· 2 shared Canpeng Li· 1 shared Cheng XieiD· 1 shared Keqin Wang· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPharmacology & Toxicology

Cheng PengORCID

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2 papers

Recent·Most cited

Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury

Yaying Zhu, Chengxiang Deng, Bo Chen, Jia He, Yanan Liu, Shan Lei, Weiju Lu, Cheng Peng, Zhao Shan

The paper identifies a stress-response program in mid-zone hepatocytes during early acute liver injury that suppresses proliferation via the Atf4-Chop-Btg2 axis.

eLife · Oct 26, 2026Peer-reviewedPharmacology & Toxicology

Differential Regulation of Hepatic Macrophage Fate by Chi3l1 in MASLD

Jia He, Bo Chen, Weiju Lu, Xiong Wang, Ruoxue Yang, Chengxiang Deng, Xiane Zhu, Keqin Wang, L Wang, Cheng Xie, RC Li, Xiaokang Lu, Ruizhi Yang, Cheng Peng, Canpeng Li, Zhao Shan

This study identifies Chi3l1 as a metabolic regulator that differentially affects hepatic macrophage fate in MASLD by modulating glucose metabolism in Kupffer cells.

bioRxiv · May 6, 2025 · PreprintPhysiology