Microbial Tryptophan Metabolism Activates Host Lysosomal Activity to Facilitate Lipid Breakdown and Ameliorate Hepatic Steatosis
Kenan Zhang, Zihan Luo, Yan Li, Yan Chen, Lang Wang, Yanan Liu, Ruizhi Yang, Qian Li, Jiahao Zhao, Bin Qi, Zhao Shan
This study identifies how bacterial tryptophan metabolism activates lysosomal function to promote lipid breakdown and reduce hepatic steatosis in both C. elegans and mice.
bioRxiv · Jun 28, 2025 · PreprintCell Biology