Bumsuk Hahm

Sphingosine 1-phosphate lyase expressed in pulmonary epithelial cells potentiates host innate defenses and alleviates influenza pathogenicity in mice

This study shows that SPL in lung epithelial cells reduces influenza severity by enhancing innate defenses and altering cell type proportions.

Sphingosine kinase 2 suppresses neutrophil responses to promote viral persistence while attenuating immune pathology

This study shows that SphK2 deficiency in neutrophils reduces immune suppression, enhances T cell responses, and decreases viral persistence during LCMV infection.