NAT10 Suppresses RNA Sensing Induced IFN-β Transactivation to Promote Viral Infection via Interfering with IRF3 Activities
Youngmin Park, Jinshan He, Suha Eleya, Zhenyu Wu, Guillaume N. Fiches, Dawei Zhou, Emily G. Watters, Zhiying He, K.A.S.N. Shanaka, Thurbu Tshering Lepcha, Yan Liu, Netty G. Santoso, Jian Kang Zhu
This study shows NAT10 suppresses IFN-β transactivation by inhibiting IRF3, thereby promoting viral infection.
bioRxiv · Sep 1, 2025 · PreprintMicrobiology