Targeted RNA degradation of HIV-1 TAR element at 5'UTR by CRISPR-Cas13X blocks HIV-1 lytic reactivation
Thurbu Tshering Lepcha, Dawei Zhou, Guillaume N. Fiches, Nithya Paruchuri, Jinshan He, Kateepe ASN Shanaka, Yan Liu, Suha Eleya, Netty G. Santoso, Jian Zhu
This study uses CRISPR-Cas13X to target HIV-1 TAR RNA, inhibiting viral reactivation and reducing viral load in infected cells.
bioRxiv · Oct 15, 2026 · PreprintMicrobiology