Janina Fuß

Epitranscriptomic profiling of VSMC phenotypes reveals uridine modifications linked to post-transcriptional regulation

The paper identifies uridine modifications in VSMCs linked to post-transcriptional regulation during atherogenic transitions using epitranscriptomic profiling.

Benchmarking porcine pancreatic ductal organoids for drug screening applications

This study benchmarks porcine pancreatic ductal organoids (PPDO) against human pancreatic ductal organoids (HPDO) and primary porcine pancreas using scRNA-Seq, showing PPDO's potential for drug screening with conserved toxicity profiles.

Evaluating Genome Sequencing Strategies: Trio, Singleton, and Standard Testing in Rare Disease Diagnosis

This study compares trio, singleton, and standard genome sequencing in rare disease diagnosis, finding trio sequencing has the highest diagnostic yield.

Quantifying The Impact of Bulk TCR-Seq Methodological Choices on The Profiled T Cell Repertoire

This study evaluates how methodological choices in bulk TCR-Seq affect T cell repertoire profiling, finding that RNA/DNA quality significantly impacts results and that low quantities can be partially compensated by increasing PCR cycles.

Genomic Evidence of Fisheries Induced Evolution in Eastern Baltic cod

The paper uses genomic data from Eastern Baltic cod to show evolutionary changes due to fishing pressure, identifying loci under directional selection linked to growth and reproduction.

Identification of lncRNAs differentially expressed in Alzheimer's disease brains using RNA sequencing

The paper identifies differentially expressed lncRNAs in Alzheimer's disease brains using RNA-seq data from multiple studies and brain regions.

Comparative analysis of novel Pseudobdellovibrionaceae genera and species yields insights into the genomics and evolution of bacterial predation mode

The paper characterizes new Pseudobdellovibrionaceae strains, revealing genomic features and evolutionary insights into bacterial predation modes.

The chromosome-level genome of the ctenophore Mnemiopsis leidyi A. Agassiz, 1865 reveals a unique immune gene repertoire

The paper presents a chromosome-level genome of Mnemiopsis leidyi, revealing unique immune gene domains and their expression in response to pathogen exposure.

Metabolic and transcriptomic analyses of nectaries reveal differences in the mechanism of nectar production between monocots (Ananas comosus) and dicots (Nicotiana tabacum)

This study compares nectar production mechanisms in monocot Ananas comosus and dicot Nicotiana tabacum using transcriptomic and metabolic analyses, revealing differences in sucrose transport and secretion.

Entorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer's disease

This study identifies four novel DNA methylation loci in the entorhinal cortex associated with Alzheimer's disease and finds significant epigenetic age acceleration in patients.

Differential microRNA expression analyses across two brain regions in Alzheimer's disease

The paper identifies differentially expressed miRNAs in two brain regions of Alzheimer's patients using qPCR and RNA-seq, highlighting potential targets involved in AD pathogenesis.

The chloroplast ribonucleoprotein CP33B quantitatively binds the psbA mRNA

The paper shows CP33B preferentially binds psbA mRNA over other chloroplast RNAs, indicating additional factors beyond the identified sequence motif contribute to its specificity.

Linked-read sequencing of gametes allows efficient genome-wide analysis of meiotic recombination

The paper develops a linked-read sequencing method to efficiently identify meiotic crossovers at kilobase resolution in pooled recombinants, validated in Arabidopsis.