Author

Luis E. Gimenez

University of MichiganORCID 0000-0002-0110-2135Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Naima S. DahiriD· 3 shared Roger D. ConeiD· 3 shared Ciria C. HernándeziD· 2 shared Alys PeisleyiD· 1 shared Anna K. MappiD· 1 shared Ashleigh M. RaczkowskiiD· 1 shared Baijie XuiD· 1 shared Chen LiuiD· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersNeuroscience

Naima S. DahirORCID

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3 papers

Recent·Most cited

Functional coupling between MC4R and Kir7.1 contributes to clozapine-induced hyperphagia

Li Li, Ciria C. Hernández, Luis E. Gimenez, Baijie Xu, Naima S. Dahir, SWATI SWATI, Shari G. Birnbaum, Roger D. Cone, Chen Liu

This study identifies a molecular pathway involving MC4R and Kir7.1 that mediates clozapine-induced hyperphagia and weight gain in mice.

bioRxiv · Jun 7, 2024 · PreprintNeuroscience

Structure of the Ion Channel Kir7.1 and Implications for its Function in Normal and Pathophysiologic States

Alys Peisley, Ciria C. Hernández, Naima S. Dahir, Laura Koepping, Ashleigh M. Raczkowski, Min Su, Masoud Ghamari‐Langroudi, Xinrui Ji, Luis E. Gimenez, Roger D. Cone

The paper presents the structure of Kir7.1, explains pathogenic mutations, and shows how a small molecule blocks the channel, affecting MC4R neurons and food intake.

bioRxiv · Jun 7, 2024 · PreprintNeuroscience

Inhibition of the melanocortin-3 receptor (MC3R) causes generalized sensitization to anorectic agents

Naima S. Dahir, Yijun Gui, Yanan Wu, Patrick R. Sweeney, Savannah Y. Williams, Luis E. Gimenez, Tomi K. Sawyer, Stephen T. Joy, Anna K. Mapp, Roger D. Cone

This study shows that inhibiting MC3R increases sensitivity to anorectic agents like GLP1, PYY, CCK, and leptin, suggesting MC3R as a negative regulator of feeding behavior.

bioRxiv · Dec 5, 2023 · PreprintNeuroscience