Author

Laura Koepping

Sanford Burnham Prebys Medical Discovery InstituteORCID 0000-0002-0132-5515Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Andrey A. BobkoviD· 2 shared Eduard A. SergienkoiD· 2 shared Jianhua ZhaoiD· 2 shared Lynn Miya FujimotoiD· 2 shared Merve DemiriD· 2 shared Taro HitosugiiD· 2 shared Alys PeisleyiD· 1 shared Ashleigh M. RaczkowskiiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

Andrey A. BobkovORCID

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Author profile →

3 papers

Recent·Most cited

Uncompetitive Allosteric Inhibitor of Mitochondrial Creatine Kinase Prevents Binding and Release of Creatine by Stabilization of Loop Closure

Merve Demir, Chen-Ting Ma, Nikhil Puvvula, Laura Koepping, Palak Gosalia, Sirkku Pollari, Shaun Alba, Zoe Zong, Ya Li, Lynn Miya Fujimoto, Andrey A. Bobkov, Taro Hitosugi, Jianhua Zhao, Eduard A. Sergienko

The paper identifies an uncompetitive allosteric inhibitor of mitochondrial creatine kinase that stabilizes loop closure, preventing creatine binding and phosphocreatine release.

Journal of Molecular Biology · Jun 9, 2026Peer-reviewedBiochemistry

Structural Basis for Substrate Binding, Catalysis and Inhibition of Breast Cancer Target Mitochondrial Creatine Kinase by Covalent Inhibitor via Cryo-EM

Merve Demir, Laura Koepping, Ya Li, Lynn Miya Fujimoto, Andrey A. Bobkov, Jianhua Zhao, Taro Hitosugi, Eduard A. Sergienko

The paper investigates the structural and mechanistic features of mitochondrial creatine kinase (uMtCK) and evaluates the efficacy of a covalent inhibitor in breast cancer cells.

Structure · Jun 18, 2024Peer-reviewedBiochemistry

Structure of the Ion Channel Kir7.1 and Implications for its Function in Normal and Pathophysiologic States

Alys Peisley, Ciria C. Hernández, Naima S. Dahir, Laura Koepping, Ashleigh M. Raczkowski, Min Su, Masoud Ghamari‐Langroudi, Xinrui Ji, Luis E. Gimenez, Roger D. Cone

The paper presents the structure of Kir7.1, explains pathogenic mutations, and shows how a small molecule blocks the channel, affecting MC4R neurons and food intake.

bioRxiv · Jun 7, 2024 · PreprintNeuroscience