Roger D. Cone

This study identifies a molecular pathway involving MC4R and Kir7.1 that mediates clozapine-induced hyperphagia and weight gain in mice.

The paper presents the structure of Kir7.1, explains pathogenic mutations, and shows how a small molecule blocks the channel, affecting MC4R neurons and food intake.

This study shows that inhibiting MC3R increases sensitivity to anorectic agents like GLP1, PYY, CCK, and leptin, suggesting MC3R as a negative regulator of feeding behavior.

This study shows that MC3R regulates AgRP neuron activation during fasting and cold exposure in a cell-autonomous manner, highlighting its role in energy homeostasis.

This study identifies cell types associated with brain complex traits using GWAS and single-cell transcriptomics, revealing novel roles for oligodendrocytes in Parkinson's disease.

The paper estimates genetic correlations between eating disorder and substance-use-related phenotypes using GWAS data, finding both positive and negative associations.

This paper uses transcriptomic imputation to identify gene-tissue associations linked to Anorexia Nervosa risk, finding significant links in both brain and metabolic tissues.