Naima S. Dahir

Estrogen Dependent Variation in the Contributions of TRPM4 and TRPM5 to Fat Taste

The paper investigates how estrogen affects fat taste signaling by examining the roles of TRPM4 and TRPM5 in Type II taste cells across different estrous phases in mice.

Functional coupling between MC4R and Kir7.1 contributes to clozapine-induced hyperphagia

This study identifies a molecular pathway involving MC4R and Kir7.1 that mediates clozapine-induced hyperphagia and weight gain in mice.

Structure of the Ion Channel Kir7.1 and Implications for its Function in Normal and Pathophysiologic States

The paper presents the structure of Kir7.1, explains pathogenic mutations, and shows how a small molecule blocks the channel, affecting MC4R neurons and food intake.

Inhibition of the melanocortin-3 receptor (MC3R) causes generalized sensitization to anorectic agents

This study shows that inhibiting MC3R increases sensitivity to anorectic agents like GLP1, PYY, CCK, and leptin, suggesting MC3R as a negative regulator of feeding behavior.

Cell autonomous regulation of the activation of AgRP neurons by the melanocortin-3 receptor

This study shows that MC3R regulates AgRP neuron activation during fasting and cold exposure in a cell-autonomous manner, highlighting its role in energy homeostasis.