NeurosciencebioRxivPreprint
Structure of the Ion Channel Kir7.1 and Implications for its Function in Normal and Pathophysiologic States
Alys Peisley, Ciria C. Hernández, Naima S. Dahir…·Roger D. Cone
The paper presents the structure of Kir7.1, explains pathogenic mutations, and shows how a small molecule blocks the channel, affecting MC4R neurons and food intake.
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