Daniela A. Grassi

This study shows that induced neurons from Huntington's disease patients have impaired autophagy in neurites, independent of protein aggregation, and that HTT is critical for neuronal autophagy.

The paper identifies a human-specific structural variation at the ZNF558 locus that regulates a gene network involved in forebrain development by controlling SPATA18 expression through a VNTR contraction.

The paper compares protein and RNA expression levels in human and chimpanzee forebrain progenitor cells, finding that protein expression differences are more common and less correlated with RNA levels.