Marie E. Jönsson

The paper shows that DNA methylation and the HUSH-MORC2 complex independently regulate repeat elements in human neural progenitor cells, with MORC2 binding increasing in demethylated regions.

This study shows L1 retrotransposons contribute to human brain transcriptome complexity and functional diversification through cell-type specific transcripts and regulatory RNAs.

The paper shows that ZNF91 creates mini-heterochromatin domains that limit the regulatory impact of SVA transposons in human neural progenitor cells, contributing to XDP pathology.

The paper uses snRNA-seq to analyze TBI brain tissue, finding oligodendroglia activate endogenous retroviruses, linking them to neuroinflammation.

This study shows that induced neurons from Huntington's disease patients have impaired autophagy in neurites, independent of protein aggregation, and that HTT is critical for neuronal autophagy.

The paper identifies a human-specific structural variation at the ZNF558 locus that regulates a gene network involved in forebrain development by controlling SPATA18 expression through a VNTR contraction.

This study shows that activation of endogenous retroviruses during brain development leads to neuroinflammation in adult mice.

The paper compares protein and RNA expression levels in human and chimpanzee forebrain progenitor cells, finding that protein expression differences are more common and less correlated with RNA levels.

The paper identifies LINE-2-derived microRNAs and their target sites in human tissues, showing their role in regulating gene expression and their disruption in glioblastoma.