Karolina Pircs

This study reprograms human dental pulp stem cells into neurons more rapidly and efficiently than fibroblasts, using a lentiviral vector and single-nucleus RNA sequencing to characterize the process.

The paper identifies phosphoproteomic changes in Huntington's disease patient-derived neurons, revealing dysregulated post-translational modifications and potential compensatory mechanisms.

This study investigates cariprazine's effects on hippocampal neurons, showing cell-type-dependent changes in excitability and network dynamics through electrophysiology and modeling.

The paper develops cell-type-specific transcriptomic aging clocks using single-nuclei RNA sequencing data from human prefrontal cortex tissue, showing distinct aging patterns across cell types.

This study examines how cardiorespiratory fitness affects epigenetic aging in different organs of rats, finding organ-specific and common changes in DNA methylation.

The paper identifies clofazimine as a drug that reduces polyQ toxicity by activating PPARγ, improving mitochondrial function in models of polyQ diseases.

This study investigates miRNA biogenesis defects in HD brain tissue, finding downregulation of key enzymes and maturation defects, primarily in the striatum.

This study generates patient-derived induced dopaminergic neurons to show age-related autophagy impairments and alpha-synuclein accumulation in Parkinson's disease.

This study shows that induced neurons from Huntington's disease patients have impaired autophagy in neurites, independent of protein aggregation, and that HTT is critical for neuronal autophagy.

The paper identifies a human-specific structural variation at the ZNF558 locus that regulates a gene network involved in forebrain development by controlling SPATA18 expression through a VNTR contraction.

This study shows that activation of endogenous retroviruses during brain development leads to neuroinflammation in adult mice.

The paper identifies LINE-2-derived microRNAs and their target sites in human tissues, showing their role in regulating gene expression and their disruption in glioblastoma.