Malin Parmar

This paper describes a method to generate dense neuronal microcultures by combining fibroblast reprogramming with matrix remodeling in collagen microgels.

The paper introduces a human stem cell-based model of the nigrostriatal pathway that mimics in vivo connectivity and reveals target-dependent dopamine neuron maturation.

This paper introduces 3D carbon cup electrodes for real-time, chemically selective detection of neurotransmitter release in midbrain organoids, demonstrating dopamine sensing and validating the platform with chemical perturbations.

The paper benchmarks dopaminergic stem cell models and cell therapy candidates using a human brain atlas to identify off-target populations and lineage plasticity.

This study investigates how co-grafting strategies influence dopamine neuron specification and maturation in a Parkinson's disease model, identifying key transcription factors involved in the process.

This study shows human neurons reprogrammed from glial progenitor cells survive and mature functionally in immunodeficient mice for up to 10 months.

This study develops a 3D microculture method to generate mature dopamine neurons from patient fibroblasts, which can be transplanted into a Parkinson's disease rat model to form functional neuron grafts.

This paper describes a method to generate human parvalbumin interneurons from glial precursor cells using direct reprogramming and identifies a distinct transcriptional profile and reprogramming trajectory.

The paper was withdrawn due to lack of full author consent and is not intended for citation.

The paper presents a minimal gene regulatory model for rostrocaudal neural tube patterning and integrates it with a dorsoventral model to predict 3D patterning and sensitivity to morphogen levels.

This study generates patient-derived induced dopaminergic neurons to show age-related autophagy impairments and alpha-synuclein accumulation in Parkinson's disease.

This study shows that induced neurons from Huntington's disease patients have impaired autophagy in neurites, independent of protein aggregation, and that HTT is critical for neuronal autophagy.

The paper evaluates TH-Cre knock-in cell lines for identifying and isolating stem cell-derived dopaminergic neurons in vitro and in vivo.

The paper uses single-cell RNA sequencing to profile fetal human midbrain dopamine neurons at different developmental stages and establishes a 3D culture system to study their functional maturation.

The paper introduces BRAVE, a method for rational AAV vector evolution that maps peptide binding motifs in vivo using barcoding and clustering.

The paper uses scRNA-seq to analyze graft composition in a Parkinson’s disease cell therapy model, revealing differences between human stem cell-derived and fetal tissue grafts.

The paper compares protein and RNA expression levels in human and chimpanzee forebrain progenitor cells, finding that protein expression differences are more common and less correlated with RNA levels.