Janelle Drouin‐Ouellet

This study investigates age-related mitochondrial impairments and mitophagy defects in human neurons using direct reprogramming and imaging.

The paper identifies phosphoproteomic changes in Huntington's disease patient-derived neurons, revealing dysregulated post-translational modifications and potential compensatory mechanisms.

This study shows that PINK1 in myeloid cells represses mtDNA release and immune signaling, which contributes to neuronal pathology in Parkinson's disease models.

This study chemically induces senescence in human microglia-like cells and shows they adopt a pro-inflammatory phenotype with reduced phagocytic and calcium activity.

The paper presents a minimal gene regulatory model for rostrocaudal neural tube patterning and integrates it with a dorsoventral model to predict 3D patterning and sensitivity to morphogen levels.

This study generates patient-derived induced dopaminergic neurons to show age-related autophagy impairments and alpha-synuclein accumulation in Parkinson's disease.

This study shows that induced neurons from Huntington's disease patients have impaired autophagy in neurites, independent of protein aggregation, and that HTT is critical for neuronal autophagy.

This study develops a quantitative model of gene regulatory interactions in neuronal reprogramming, showing that PTB and nPTB interactions are critical for predicting reprogramming outcomes.