Author

Jillian Caiazzi

University of Massachusetts Chan Medical SchoolORCID 0000-0002-7077-2116Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 2 Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Organism:plant (other)· 1 Organism:rat· 1

Frequent Co-Authors

Anastasia KhvorovaiD· 4 shared Dimas EcheverriaiD· 4 shared Nicholas McHughiD· 3 shared Samuel R. HildebrandiD· 3 shared Ashley SummersiD· 2 shared David CooperiD· 2 shared Hassan H. FakihiD· 2 shared Julia F. AltermaniD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersNeuroscience

Anastasia KhvorovaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model

Vignesh Narayan Hariharan, Ashley Summers, Amy E. Clipperton‐Allen, Jillian Caiazzi, Samuel R. Hildebrand, Daniel O’Reilly, Qi Tang, Zachary Kennedy, Dimas Echeverria, Nicholas McHugh, David Cooper, Jacquelyn Sousa, Chantal Ferguson, Hassan H. Fakih, Laurent P. Bogdanik, , Anastasia Khvorova

Therapeutic siRNAs provide safe and durable modulation of MECP2 for the treatment of mild and severe MECP2 Duplication Syndrome.

Nature Communications · Jul 21, 2026Peer-reviewedNeuroscience

Organyl 5'-Phosphates in siRNA Guide Strands: Structure-Function Relationships Governing Anchoring in Argonaute 2 and Metabolic Stability

Theodore Carrigan-Broda, Luca F. R. Gebert, Samuel R. Hildebrand, Nozomi Yamada, Eric Luu, Jillian Caiazzi, Nicholas McHugh, Dimas Echeverria, Atish A. Wagh, Jonathan K. Watts, Anastasia Khvorova, Ian J. MacRae, Ken Yamada

This study identifies organyl 5'-phosphate mimics that enhance AGO2 binding and metabolic stability by interacting with a hydrophobic pocket in the MID domain.

bioRxiv · Feb 14, 2026 · PreprintMolecular Biology

Potent and durable gene modulation in heart and muscle with chemically defined siRNAs

Hassan H. Fakih, Clemens Lochmann, Rosemary Gagnon, Ashley Summers, Jillian Caiazzi, Julianna E. Buchwald, Qi Tang, Bruktawit Maru, Samuel R. Hildebrand, Mohammad Zain UI Abideen, Raymond C. Furgal, Katherine Y. Gross, Yeon-Suk Yang, David Cooper, Kathryn R. Monopoli, , Anastasia Khvorova

This study develops chemically defined siRNAs for durable gene modulation in muscle and heart, showing long-term silencing and functional benefits with minimal toxicity.

Nucleic Acids Research · Nov 26, 2025Peer-reviewedPharmacology & Toxicology

Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in rodent and swine photoreceptors

Shun-Yun Cheng, Jillian Caiazzi, Annabelle Biscans, Julia F. Alterman, Dimas Echeverria, Nicholas McHugh, Matthew R. Hassler, Samson M. Jolly, Delaney Giguere, Joris Cipi, Anastasia Khvorova, Claudio Punzo

This study evaluates tetravalent siRNA configurations for photoreceptor gene silencing, finding that tetravalent siRNA provides robust, long-lasting efficacy with a good safety profile in rodent and swine models.

Molecular Therapy — Nucleic Acids · Dec 5, 2023Peer-reviewedNeuroscience