Author

Sierra Smith

Duke UniversityORCID 0000-0002-0120-8765Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Approach:statistical model· 1 Organism:zebrafish· 1

Frequent Co-Authors

Akankshi MunjaliD· 1 shared Albert L. MiskoiD· 1 shared Jiacheng WangiD· 1 shared Kira L. HeikesiD· 1 shared Luk H. VandenbergheiD· 1 shared Madison SangsteriD· 1 shared Monica Salani· 1 shared Nadia ElioraiD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperDevelopmental Biology

Akankshi MunjalORCID

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2 papers

Recent·Most cited

Versican controlled by Lmx1b regulates hyaluronate density and hydration for semicircular canal morphogenesis

Yusuke Mori, Sierra Smith, Jiacheng Wang, Nadia Eliora, Kira L. Heikes, Akankshi Munjal

The paper identifies Lmx1b as a regulator of hyaluronan and Versican in zebrafish inner ear semicircular canal morphogenesis, showing how Versican controls hyaluronate density and hydration through its core and chondroitin side chains.

Development · Dec 9, 2024Peer-reviewedDevelopmental Biology

MCOLN1 gene-replacement therapy corrects neurologic dysfunction in the mouse model of mucolipidosis IV.

Samantha DeRosa, Monica Salani, Sierra Smith, Madison Sangster, Victoria Miller-Browne, Sarah Wassmer, Ru Xiao, Luk H. Vandenberghe, Susan A. Slaugenhaupt, Albert L. Misko, Yulia Grishchuk

This study demonstrates that AAV-mediated MCOLN1 gene transfer improves motor function and reduces brain pathology in a mouse model of mucolipidosis IV.

Human Molecular Genetics · Apr 2, 2021Peer-reviewedGenetics