Author

Samantha DeRosa

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Albert L. MiskoiD· 1 shared Bruce A. RheaumeiD· 1 shared Ephraim F. TrakhtenbergiD· 1 shared Jian Xing· 1 shared Luk H. VandenbergheiD· 1 shared Madison SangsteriD· 1 shared Monica Salani· 1 shared Ru XiaoiD· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenetics

Albert L. MiskoORCID

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2 papers

Recent·Most cited

CellTools algorithm for mapping scRNA-seq query cells to the reference dataset improves the classification of resilient and susceptible retinal ganglion cell types

Bruce A. Rheaume, Jian Xing, William C. Theune, Samantha DeRosa, Ephraim F. Trakhtenberg

The paper introduces CellTools, an algorithm that improves scRNA-seq cell mapping and classification, revealing new insights into retinal ganglion cell resilience to injury.

bioRxiv · Oct 15, 2021 · PreprintBioinformatics

MCOLN1 gene-replacement therapy corrects neurologic dysfunction in the mouse model of mucolipidosis IV.

Samantha DeRosa, Monica Salani, Sierra Smith, Madison Sangster, Victoria Miller-Browne, Sarah Wassmer, Ru Xiao, Luk H. Vandenberghe, Susan A. Slaugenhaupt, Albert L. Misko, Yulia Grishchuk

This study demonstrates that AAV-mediated MCOLN1 gene transfer improves motor function and reduces brain pathology in a mouse model of mucolipidosis IV.

Human Molecular Genetics · Apr 2, 2021Peer-reviewedGenetics