Targeted Protein Degradation in Escherichia coli - depletion of the essential GroEL using CLIPPERs
Matylda Anna Izert, Maria Magdalena Klimecka, Anna Antosiewicz, Karol Wróblewski, Jakub Józef Kowalski, Katarzyna Justyna Bandyra, Tomasz Goral, Sebastian Kmiecik, Remigiusz Adam Serwa, Maria W. Górna
This paper introduces a method for targeted protein degradation in bacteria using degrader peptides that exploit the ClpXP protease, demonstrating its effectiveness on the essential GroEL protein.
bioRxiv · Feb 29, 2024 · PreprintMolecular Biology